FIG 7.
Abnormality of the Keap1FA/–::Nrf2SA/SA mouse esophageal epithelium. (A to C) Immunohistochemistry of keratin 14 (A), loricrin (B), and Ki67 (C). The yellow dotted lines show the boundary of the epithelial cell layer. (D, E) mRNA levels of keratin 5 (D, left panel), keratin 14 (D, right panel), and loricrin (E). Hprt was used as the internal control. The mRNA levels in the Keap1+/+::Nrf2+/+ mice were set to 1. (F) Number of Ki67-positive cells per section. The bar graphs show the means ± SD. **, P < 0.01, and *, P < 0.05, by one-way ANOVA with Tukey’s multiple-comparison test.