Table 1.

Association estimates for SNPs associated with biomarkers of iron status at genome-wide significance identified from the Genetics of Iron Status Consortium GWAS meta-analysis.

				Serum iron, μmol/L			Transferrin saturation, %			Log10 ferritin, mg/L			Transferrin, g/L
SNPs	Gene	EA	EAF	Beta	SE	P	Beta	SE	P	Beta	SE	P	Beta	SE	P
rs1800562*	HFE	A	0.07	0.328	0.016	2.9 × 10–92	0.577	0.016	2.2 × 10–270	0.204	0.016	1.5 × 10–38	-0.479	0.016	8.9.×10–196
rs1799945*	HFE	G	0.15	0.189	0.01	1.1 × 10–81	0.231	0.01	5.1 × 10–109	0.065	0.01	1.7 × 10–10	–0.114	0.01	9.4 × 10–30
rs855791*	TMPRSS6	G	0.55	0.181	0.007	4.3 × 10–139	0.19	0.007	6.4 × 10–137	0.055	0.007	1.4 × 10–14	–0.044	0.007	2.0 × 10–9
rs8177240	TF	G	0.35	0.066	0.007	6.6 × 10–20	0.1	0.008	7.2 × 10–38	NA	NA	NA	0.38	0.007	8.4 × 10–610
rs7385804	TFR2	A	0.62	0.064	0.007	1.4 × 10–18	0.054	0.008	6.1 × 10–12	NA	NA	NA	NA	NA	NA
rs744653	AC013439.4	C	0.16	NA	NA	NA	NA	NA	NA	0.089	0.01	8.4 × 10–19	NA	NA	NA
rs411988	TEX14	G	0.44	NA	NA	NA	NA	NA	NA	0.044	0.007	1.6 × 10–10	NA	NA	NA
rs651007	ABO	C	0.79	NA	NA	NA	NA	NA	NA	0.05	0.009	1.3 × 10–8	NA	NA	NA
rs4921915	NAT2	A	0.76	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.079	0.009	7.1 × 10–19
rs174577	FADS2	A	0.36	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.062	0.007	2.3 × 10–17
rs9990333	TFRC	C	0.53	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.051	0.007	2.0 × 10–13
rs6486121	ARNTL	C	0.34	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.046	0.007	3.9 × 10–10

EA = effect allele, EAF = effect allele frequency, NA = not applicable, SE = standard error, SNP = single nucleotide polymorphism.

^*SNPs used in the main MR analyses.