Table 2.

Biological effects of genes corresponding to used SNPs on systemic iron status.

SNPs	Corresponding gene	Link to iron status	References (PMID)
rs1800562	HFE	HFE can regulate iron uptake by competitively inhibiting the TRF1 transferrin receptor.[12]	8696333
rs1799945		HFE protein can enhance the iron transport regulator hepciden by binding to TFR2, thereby inhibiting the intestinal enterocyte and macrophage iron export protein ferroportin.[13]	19254567
rs855791	TMPRSS6	TMPRSS6 increases iron uptake by inhibiting hepciden production during systemic iron depletion.[14]	25550162

SNP = Single-nucleotide polymorphisms, HFE = hemochromatosis, TMPRSS6 = transmembrane protease serine 6 gene, TRF = transferrin receptor.