Table 4.
Association of AGTR1 gene polymorphism, methylation and lipid metabolism with hypertension using the logistic regression analysis.
| β | SE | Wald χ2 | P | OR (95% CI) | |
|---|---|---|---|---|---|
| AGTR1 rs275653/AA | — | — | 0.537 | .765 | — |
| AGTR1 rs275653/AG | −0.035 | 0.169 | 0.043 | .836 | 0.965 (0.693–1.346) |
| AGTR1 rs275653/GG | 0.542 | 0.783 | 0.479 | .489 | 1.719 (0.371–7.976) |
| AGTR1 methylation | −0.056 | 0.028 | 3.952 | .047 | 0.946 (0.896–0.999) |
| TG (mmol/L) | 0.084 | 0.109 | 0.591 | .442 | 1.088 (0.878–1.348) |
| TC (mmol/L) | 0.119 | 0.101 | 1.381 | .240 | 1.127 (0.923–1.374) |
| HDL (mmol/L) | −0.181 | 0.337 | 0.287 | .592 | 0.835 (0.431–1.617) |
Values in bold are significant at P < 0.005.
Adjusted for age, gender, body mass index, education, smoking, alcohol drinking, fruit and vegetable intake, pickles intake, and family history of hypertension.
AGTR1 = angiotensin II receptor type 1, CI = confidence interval, HDL = high-density lipoprotein, OR = odds ratio, TC = total cholesterol, TG = triglyceride.