TABLE 3.
Analysis of clinical and pathological factors for the success of NGS analysis in TBB samples
| Variables | n = 99 (%) | Univariate | Multivariate | ||
|---|---|---|---|---|---|
| ORR (95% CI) | p | ORR (95% CI) | p | ||
| Age, years | |||||
| ≤64 | (35.4) | 1 | Reference | ||
| >64 | (64.6) | 1.020 (0.343–3.050) | 0.968 | ||
| Sex | |||||
| Male | (58.6) | 1 | Reference | ||
| Female | (41.4) | 0.717 (0.242–2.130) | 0.549 | ||
| Histology | |||||
| Adenocarcinoma | (75.8) | 1 | Reference | 1 | Reference |
| Others | (24.2) | 0.158 (0.019–1.25) | 0.081 | 0.218 (0.020–2.36) | 0.210 |
| Tumor location 1 | |||||
| Peripheral | (65.7) | 1 | Reference | ||
| Central | (34.3) | 0.747 (0.239–2.330) | 0.616 | ||
| Tumor location 2 | |||||
| Right upper/lower | (53.5) | 1 | Reference | ||
| Left upper/lower | (46.5) | 0.772 (0.477–1.250) | 0.291 | ||
| Maximum diameter of tumor (mm) (range) | |||||
| 40.3 (14.7–102.3) | (100) | 0.96 (0.924–0.998) | 0.040 | 0.98 (0.934–0.1.03) | 0.358 |
| Tumor nuclei content (%) (range) | |||||
| 50 (10–90) | (100) | 2.020 (0.702–5.790) | 0.192 | 1.380 (0.401–4.73) | 0.611 |
| Necrosis tissue content. (%) (range) | |||||
| 10 (0–90) | (100) | 0.204 (0.025–1.640) | 0.135 | 0.390 (0.038–4.02) | 0.429 |
| Tissue confirmation | |||||
| Confirmed | (83.8) | 1 | Reference | 1 | Reference |
| Unconfirmed | (16.2) | 11.9 (3.480–40.60) | <0.001 | 11.1 (2.960–41.80) | <0.001 |