Table 3:
Outcomes after hematopoietic cell transplant in t-AML patients
| Total patients |
Age (median, range) |
Overall survival (%) |
Non-relapse or treatment- related mortality (%) |
Relapse (%) | |
|---|---|---|---|---|---|
| Sengsayadeth [64] | 4997 | 58 (IQR, 50-64) | 2-yr survival: 45 | 2-yr: 27 | 2-yr: 34% |
| Alam [16] | 65 | 53 (19-69) | 2-yr: 34* | 2-yr: 31 | 2-yr: patients <60 years: 30, >60 years: 36 |
| Litzow [26]† | 868 | 40 (4-72) | 1-yr: 32, 5-yr 21 | 1-yr: 41 | 1-yr: 27, 5-yr: 31 |
| Yakoub-Agha [65] | 70 | 2-yr: 30 | 2-yr: 49 | 2-yr: 42 | |
| Kroger [66]† | 461 | 40 (3-69) | 3-yr: 35 | 3-yr: 37 | 3-yr: 31 |
| Finke [88] | 79 | 58 (20-76) | 5-yr: 38, 10-yr 24% | 5-yr: 23, 10-yr 32 | 5-yr: 42, 10-yr: 44 |
Favorable, intermediate, and unfavorable cytogenetics had 2-year overall survival of 53%, 44%, and 21% respectively.
includes both t-AML and t-MDS
CR- complete remission, IQR- Inter-quartile range, t-AML- therapy related acute myeloid leukemia, t-MDS- therapy related myelodysplastic syndrome