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. 2022 Jan 31;2(3):282–296. doi: 10.1021/acsbiomedchemau.1c00050

Figure 10.

Figure 10

Compound 7 enhances mitochondrial function and FFA oxidation. (A) Relative RNA expression of Errα, Pdk4, Atp5β, Pgc1α, Mcad, and cpt1a in response to compound 7; (B) western blot analysis on the liver with ERRα, PKD4, MCAD, and ATP5β; (C) relative RNA expression of Cs, TfII, CoxII, Sdh, Acat2, Cyp4a12b, and Aldh1b1 in response to compound 7; (D) compound 7 enhances the expression of mitochondria DNA; (E) compound 7 enhances the activity of CS and FFA oxidation (F); and (G) western blot analysis on the liver with AOX1, Cytochrome C, SDH, and Cpt1A. (H) Electron microscopic analysis and (I) O2 consumption. *p < 0.05, compound 7 compared with PBS mice during a 12 h light/dark cycle, #p < 0.05, HFD group compared with LFD mice, n = 5.