Figure 5.

The impact of systemic DCZ administration on socio-emotional behavior and probabilistic learning. A, The effect of low-dose DCZ in the human intruder task. Bars represent the mean time spent motionless with systemic administration of vehicle (gray) or low-dose DCZ (light blue) in alone condition (left), profile condition (middle), or stare condition (right). Symbols represent individual animals. Error bars indicate SE. B, Dosage-dependent changes in RT in the probabilistic learning task. Bar plots represent the mean RT of 3 subjects in each drug condition (vehicle, low-dose DCZ, high-dose DCZ). Error bars indicate SE. Symbols represent individual subjects. *Significant main effect of drug condition (p = 2.5 × 10⁻⁶, one-way repeated-measures ANOVA). C, Relationship between RT and functional connectivity across conditions in the probabilistic learning task. Scatter plots represent the RT in each behavioral session (y axis) and the change in overall functional connectivity in a corresponding subject (x axis) for cortical areas (left) and for subcortical areas (right), respectively. Individual monkeys completed 6-8 behavioral sessions per each condition. Colors represent drug conditions. Solid and dotted lines indicate linear fitting and CIs, respectively. Red lines indicate significant linear correlation between RT and z value (p = 0.023).