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. Author manuscript; available in PMC: 2022 Oct 6.
Published in final edited form as: Matter. 2021 Sep 22;4(10):3195–3216. doi: 10.1016/j.matt.2021.09.004

Figure 5: CryoFold samples several biologically relevant states of the soluble domain of mitochondrial F1 - F0 ATPsynthase.

Figure 5:

We modeled mitochondrial F1 - F0 ATPsynthase starting from pdb 6RET (state I) and excluding the grey region embedded in the membrane from refinement. CryoFold samples different conformations through a hinge motion in the OSCP region (orange) connecting the arm (blue) with the rotary domains (cyan). Clustering and 2D-RMSD analysis shows Cryofold samples conformations of additional ATPsynthase states represented by pdb codes 6RDK, 6RDL (state IV). Ohter states represented by pdb codes 6RDQ, 6RDR (state II) and 6RDW, 6RDX (state III) are included in SI.