Table 5.

Enzymes that are suggested to be involved in the baseline turnover of ECMs.

Enzyme	Animal	Description	Section	Ref
Mmp1	Drosophila	Mmp1 mutants show ~20% slower turnover of type IV collagen compared to control.	3.3	[50]
CTSK	Mouse	A CTSK inhibitor odanacatib causes collagen accumulation in cultured tendon.	3.6	[103]
AdamTS-A	Drosophila	Its loss and overexpression increases and decreases type IV collagen level, respectively.	3.3	[90]
ADAM17	Mouse	Expression level oscillates with a 24-hour rhythm in the intervertebral discs.	3.6	[105]
ADAMTS1	Mouse	Expression level oscillates with a 24-hour rhythm in the intervertebral discs.	3.6	[105]
ADAMTS15	Mouse	Expression level oscillates with a 24-hour rhythm in the intervertebral discs.	3.6	[105]