TABLE 1.

Regulation of circRNA biogenesis by specific RBPs and their role in disease

circRNA	Gene	RBP	RBP function	Disease and effect	Ref
circ0006916	HOMER1	TNRC6A	Binding to flanked intron regions, promotion of circ0006916 production	Use of TNRC6A as a possible strategy to increase circ0006916 levels in lung cancer cells, where the expression of this circRNA is downregulated. Regulation of cell cycle and proliferation.	142
SCD‐circRNA 2	SCD	RBM3	Binding to flanking regions, promotion of SCD‐circRNA 2 biogenesis	In hepatocellular carcinoma, upregulation of both SCD‐circRNA 2 and RBM3. Regulation of cell cycle.	143
circAMOTL1L	AMOTL1	RBM25	Promotion of circAMOTL1L biogenesis	In prostatic cancer, downregulation of both circAMOTL1L and RBM25 due to lower p53 activity. Regulation of EMT.	144
TTN‐derived circRNAs	TTN	RBM20	Promotion of biogenesis of a specific circRNAs subset from the titin gene I‐band. Alternative backsplicing.	In dilated cardiomyopathy, RBM20 activity is lost, and a complete set of circRNAs together with it.	145