Skip to main content
. 2022 Jul 21;17(7):e0271725. doi: 10.1371/journal.pone.0271725

Fig 4. H3K4ac is regulated in response to bazedoxifene treatment in MCF7 cells.

Fig 4

Clustering of 130 differentially enriched H3K4ac marked regions reveals two distinct epigenetic signatures. A) Heatmap of enrichment profiles across genomic regions within 4kb of H3K4ac sites clustered using k-means (k = 3). B) Aggregated mean profiles of clusters identified in A; the x-axis corresponds to the mean normalized fold-enrichment values. C) Distance by cluster from each site to the nearest transcript start site (TSS) of a protein-coding gene. D) Distance by cluster from each site to the nearest ERα peak. E) KEGG enrichment analysis of pathways associated with genes nearby cluster 1 and 2 promoter proximal regions (TSS) or cluster 3 enhancer (ENH) regions.