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. 2022 Jul 7;9:878229. doi: 10.3389/fnut.2022.878229

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Copyright © 2022 Jia, Wu, Wang, Kan, Zhang, Zhang, Zhang, Li, Xu, Du and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PP2 largely promoted the proliferation of C2C12 cells. (A) Effect of PP1, PP2, PP3, PP4, and PP5 on the growth of C2C12 cells; (B) effect of PP1, PP2, PP3, PP4, and PP5 on the expression of IGF-1R, p-AMPK, t-AMPK, cyclin D1, and CDK6; (C) statistical analysis of cyclin D1 expression; (D) statistical analysis of CDK6 expression; (E) statistical analysis of p-AMPK/t-AMPK expression; (F) statistical analysis of IGF-1R expression. The significant difference between groups was validated with one-way ANOVA using GraphPad Prism 6, *p < 0.05, **p < 0.01, ***p < 0.001 vs. CN group (n = 5/group). Data are presented as mean ± standard deviation (M ± SD).