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. 2022 Jul 21;17(7):e0269982. doi: 10.1371/journal.pone.0269982

Table 4. Hazard/Subhazard ratio of outcomes in statin users in comparison to nonusers.

Outcome Hazard ratio 95% confidence interval p-value
Secondary analysis
Propensity score matched cohort (81,146 statin users and 81,146 nonusers)
    Incident CKD 1.20 1.16–1.25 <0.001
    Incident Diabetes with ophthalmic manifestations 1.35 1.26–1.44 <0.001
    Incident Diabetes with neurological manifestations 1.19 1.15–1.24 <0.001
Propensity score matched cohort with death as a competing risk factor (81,146 statin users and 81,146 nonusers)
    Incident CKD 1.13* 1.09–1.17 <0.001
    Incident Diabetes with ophthalmic manifestations 1.28* 1.20–1.37 <0.001
    Incident Diabetes with neurological manifestations 1.19* 1.15–1.24 <0.001
Post-Hoc analysis
Intensive cholesterol lowering statin users in comparison to nonusers in the overall cohort with death as a competing risk factor (38,823 statin users and 110,195 active comparators)
    Incident CKD 1.57* 1.51–1.64 <0.001
    Incident Diabetes with ophthalmic manifestations 1.71* 1.59–1.83 <0.001
    Incident Diabetes with neurological manifestations 1.30* 1.24–1.36 <0.001

*Subhazard ratio