Table 4.
Spearman correlation between the top candidate PEA biomarkers and established biomarkers
| Biomarker | NT-proBNP | cTnT-hs | Cystatin C | Il-6 | CRP |
|---|---|---|---|---|---|
| cTnT-hs | 0.38 | – | 0.48 | 0.31 | 0.14 |
| NT-proBNP | – | 0.38 | 0.41 | 0.26 | 0.14 |
| IL-6 | 0.26 | 0.31 | 0.28 | – | 0.52 |
| GDF-15 | 0.35 | 0.50 | 0.52 | 0.36 | 0.17 |
| suPAR | 0.33 | 0.40 | 0.55 | 0.38 | 0.27 |
| FGF-23 | 0.11 | 0.18 | 0.21 | 0.20 | 0.16 |
| TRAILR2 | 0.39 | 0.49 | 0.64 | 0.37 | 0.20 |
| TNFR1 | 0.29 | 0.45 | 0.64 | 0.33 | 0.24 |
| TFF3 | 0.34 | 0.44 | 0.59 | 0.24 | 0.12 |
| CTSL1 | 0.14 | 0.18 | 0.20 | 0.17 | 0.17 |
Correlation values presented from the identification cohort.
CRP, C-reactive protein; cTnT-hs, cardiac troponin T; CTSL1, cathepsin L1; FGF-23, fibroblast growth factor 23; GDF-15, growth differentiation factor 15; IL-6, interleukin-6; NT-proBNP, N-terminal pro-B-type natriuretic peptide; suPAR, urokinase receptor; TFF3, trefoil factor 3; TNFR1, tumour necrosis factor receptor 1; TRAILR2, TNF-related apoptosis-inducing ligand receptor 2.