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. 2021 Jul 16;118(9):2085–2102. doi: 10.1093/cvr/cvab240

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© The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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cGMPopathies and evidence-based therapies. Potential combinatorial cGMP therapies in cardiovascular applications. Blue dashed lines show drugs in clinical trials, whereas solid blue lines approved drugs. Red lines show limitations of usage in these indications. ARNI, angiotensin receptor-neprilysin inhibitor; GC-A/Bs, GC-A/B stimulators; NOd, NO donors; HNOd, nitroxyl donors; NOSr, NOS recoupling drugs; PDEi, PDE inhibitors; sGCs/a, sGC stimulators/activators. Created with BioRender.com.