Table 1.
cGMP-related loci. Identified to be associated with cardiovascular diseases by genome-or exome-wide association studies. NPPA genetic variant rs5068 and GUCY1A3 variant α1-A680T may protect against metabolic syndrome and PH, respectively
| Gene | Chromosome | Association with |
|---|---|---|
| ANP [NPPA] | 1 | AF23, BP17, MetS24, VR178 |
| BNP [NPPB] | 1 | BP17 |
| Furin [PCSK3] | 15 | BP17, MI/CAD179 |
| eNOS [NOS3] | 7 | BP180, CAD181, MetS19 |
| NPR1 [NPR1] | 1 | BP22, VR178 |
| PDE5A [PDE5A] | 4 | CAD18 |
| sGCα1 [GUCY1A3] | 4 | BP17,182, PH183 |
| sGCα1 [GUCY1A3] + CCTη [CCT7] | 4+2 | MI/CAD21 |
| sGCβ1 [GUCY1B3] | 4 | BP17,182 |
AF, atrial fibrillation; BP, blood pressure; CAD, coronary artery disease; CCT7, chaperonin containing TCP1 subunit 7; MetS, metabolic syndrome; MI, myocardial infarction; PH, pulmonary hypertension; VR, ventricular remodelling.