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. 2022 Jul 8;163(8):bqac103. doi: 10.1210/endocr/bqac103

Figure 6.

Figure 6.

Increased pulsatile GH secretion in VGAT GHR KO mice. A and B, Representative examples of the pulsatile pattern of GH secretion in 8-week-old control, VGAT GHR KO, and VGLUT2 GHR KO mice both in A, males, and B, females. C and D, Mean GH levels, GH pulse amplitude, GH pulse frequency, and serum IGF-1 levels in 8-week-old control (n = 10-32), VGAT GHR KO (n = 10-13), and VGLUT2 GHR KO (n = 7-19) male mice. E and F, Mean GH levels, GH pulse amplitude, GH pulse frequency, and serum IGF-1 levels in 8-week-old control (n = 13-27), VGAT GHR KO (n = 5-9), and VGLUT2 GHR KO (n = 8-14) female mice. *P < .05; **P < .01; ***P < .001 (1-way ANOVA and Newman-Keuls multiple comparisons test). ANOVA, analysis of variance; GH, growth hormone; GHR, GH receptor; IGF-1, insulin-like growth factor 1; KO, knockout; VGAT, vesicular inhibitory amino acid transporter.