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. 2022 Jul 8;163(8):bqac103. doi: 10.1210/endocr/bqac103

Figure 7.

Figure 7.

Increased hypothalamic Ghrh and hepatic Igf1 mRNA levels in VGAT GHR KO mice. A, Hypothalamic gene expression in 8-week-old control (n = 12), VGAT GHR KO (n = 8), and VGLUT2 GHR KO (n = 6) male mice. B, Hepatic gene expression in 8-week-old control (n = 10), VGAT GHR KO (n = 4), and VGLUT2 GHR KO (n = 6) male mice. C, Pituitary gene expression in control (n = 7-10), VGAT GHR KO (n = 4-8), and VGLUT2 GHR KO (n = 7) male mice. D, Hypothalamic gene expression in 8-week-old control (n = 8), VGAT GHR KO (n = 6), and VGLUT2 GHR KO (n = 4) female mice. E, Hepatic gene expression in 8-week-old control (n = 9), VGAT GHR KO (n = 6), and VGLUT2 GHR KO (n = 5) female mice. F, Pituitary gene expression in control (n = 6), VGAT GHR KO (n = 6), and VGLUT2 GHR KO (n = 7) female mice. *P < .05; **P < .01; ***P < .001 (1-way ANOVA and Newman-Keuls multiple comparisons test). ANOVA, analysis of variance; GH, growth hormone; GHR, GH receptor; IGF-1, insulin-like growth factor 1; mRNA, messenger RNA; KO, knockout; VGAT, vesicular inhibitory amino acid transporter.