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. 2022 Jul 19;99(3):e245–e257. doi: 10.1212/WNL.0000000000200358

Figure 3. Relationship of Plasma p-tau181 With CSF Aβ42/Aβ40 and Amyloid PET.

Figure 3

Plasma p-tau181 was transformed with the natural logarithm for analysis. The relationship between plasma p-tau181 and CSF Aβ42/Aβ40 (A) or amyloid PET Centiloid (C) was evaluated by partial Spearman correlation and was adjusted for age, sex, APOE ε4 carrier status, self-identified race, and cognitive status. Vertical dotted lines represent cutoff values for amyloid positivity. Plasma p-tau181 levels for African American (AA) and non-Hispanic White (NHW) groups were evaluated by CSF Aβ42/Aβ40 status (positive <0.0673) (B) or amyloid PET status (D). Cutoff values for plasma p-tau181 with the highest combined sensitivity and specificity for distinguishing amyloid status were selected and are denoted by horizontal dashed lines. The receiver operating characteristic area under the curve (ROC AUC), positive percent agreement (PPA), and negative percent agreement (NPA) are shown. Point types denote the following: race: red, AA; black, NHW; cognitive status: open circle, Clinical Dementia Rating (CDR) 0; closed square, CDR > 0.