Table 4.

Human metabolic generic models and cancer models.

Model	Scale	No. of Reactions	No. of Metabolite	No. of Genes	Web link
HMR 1 (185)	Genome	8174	6006	3674	https://metabolicatlas.org/gems/repository/366
HMR 2 (186)	Genome	8181	6007	3765	https://metabolicatlas.org/gems/repository/367
Recon 1 (183)	Genome	3741	2766	1905	http://bigg.ucsd.edu/models/RECON1
Recon 2 (184)	Genome	7440	5063	2194	https://www.ebi.ac.uk/biomodels/MODEL1109130000
Recon 3D (103)	Genome	10600	5835	2248	https://www.vmh.life/#downloadview http://bigg.ucsd.edu/models/Recon3D
Human1 (187)	Genome	13069	8366	3067	https://github.com/SysBioChalmers/Human-GEM
Cancer central metabolism (140)	Small	80	66	46	https://doi.org/10.1371/journal.pone.0012383
iCancer-Core (iHCC2578) (151, 166)	Genome	7762	5566	2892	https://github.com/sysmedicine/phd2020/tree/master/GEM/data
C2M2N (164)	Small	77	54	–	https://doi.org/10.3390/metabo9050081
HMRcore (131, 188)	Intermediate	315	256	418	https://github.com/BIMIB-DISCo/scFBA
Central Carbon (141)	Small	114	120	–	https://doi.org/10.1042/bst20150149
iMS570 (brain) (189)	Genome	630	524	570	http://dx.doi.org/10.1016/j.fob.2014.05.006

This table describes various human reconstructions that are used as the starting reference models in various cancer applications listed in Table 3 . The most updated online links to these models may be different than previously described in their original manuscripts.