Fig. 5.

Transactivation activity of ribosomal protein S19 (RPS19) is reduced by luteolin and quercetin through reduction of Akt/mTOR/cMyc signaling. Transactivation of RPS19 was measured by treatment of A431-III cells with 10 and 20 μM of luteolin (A), 20 and 40 μM of quercetin (B), 5 and 10 μM of LY294002 (C), 200 and 400 μM of 10058-F4 (D) for 24 h. Data represent the mean (SD) of three different experiments. Statistical significance was determined by a one-way ANOVA with Tukey's test (*P < 0.05, **P < 0.01, and ***P < 0.001).