Fig. 7.

Ribosomal protein S19 (RPS19) increases the migratory and invasive abilities of cancer cells. A wound-healing experiment was used to analyze cell migration after RPS19 overexpression in A431-P cells (A, C) and RPS19 shRNA knockdown in A431-III cells (B, D). A trans-well assay was used to analyze the invasive ability with RPS19 overexpression in A431-P cells (E, G) and RPS19 shRNA knockdown in A431-III cells (F, H). Migration and invasion cells were calculated and analyzed by ImageJ software. Statistical significance between the groups was determined from three separate experiments with an unpaired Student's t-test. Results from three independent experiments are expressed as the mean ± standard deviation (SD). Statistical significance was determined by a one-way ANOVA with Tukey's test (*P < 0.05, **P < 0.01, and ***P < 0.001).