Figure 9.

Schematic representation of binding modes for a ligand aromatic moiety to a quadruplex outer tetrad. (A) Intercalation between G‐tetrad and base pair at a Q‐D junction. (B) Stacking on outer tetrad in‐plane with an interfacial base pair at the junction. (C) Stacking on outer tetrad in‐plane with an overhang or loop residue of an isolated quadruplex without Q‐D interface. Arrows indicate direction of major π–π stacking, electrostatic, and/or hydrogen bond interactions of the orange‐colored ligand; bases of the G‐tetrad, base pair, and overhang or loop are colored gray, red, and magenta, respectively.