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Model for how P-body architecture regulates MARF1-mediated mRNA decay. In the presence of intact P-bodies, the MARF1–EDC4 interaction leads to the sequestration of MARF1 to P-bodies in a way that inhibits its RNA-binding and mRNA decay potential. By ablating endogenous P-bodies, MARF1 exists in an active form that can robustly decay target mRNAs.
