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Model for the organisation of replication initiation zones in the human genome. Ini-seq 2 origins define early replicating regions of the genome with an ‘open’ chromatin structure. The borders of initiation zones are defined by the most efficient origins and local gene organisation that will minimise head-on transcription,i.e. the core of the initiation zone is depleted in genes but enriched at the boundary with genes co-orientated with the direction of leading strand replication.
