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Functionalisation of DNA during solid phase oligonucleotide chemistry. (A) Reaction of a phosphite triester with the sulfonyl azide and subsequent completion of the DNA synthesis. (B) Comparison of the positioning of a chemical modification in a DNA helix by special phosphoramidites where it is placed in the major groove and this work where it is placed on the phosphate edge of the helix (Only one diastereomer of the sulfonylphosphoramidate is shown).
