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Slow‐binding at HDAC1: The apparent first‐order rate constant k obs (mean ±SD) plotted against the corresponding inhibitor concentrations [I]. The resulting curves were fitted to Eq. 5. A) 6 d, the relationship between k obs and [I] indicates slow‐binding Mechanism II; B) 10 c, the relationship between k obs and [I] indicates slow‐binding Mechanism II; C) VK‐1, the relationship between k obs and [I] indicates slow‐binding Mechanism II. Experiments were performed in triplicates.
