Table 1.
TS-ASO sequences obtained from the hepatotoxicity screeninga
| Number of motifs | |||||
|---|---|---|---|---|---|
| Name | Sequence | TGC | TCC | AST (Ul–1) | ALT (Ul–1) |
| TS1-ASO | GTTATGCCACCCTA | 1 | 0 | 9437 | 15 602 |
| TS2-ASO | GTCCGCATGCCTAA | 1 | 1 | 1364 | 1617 |
| TS3-ASO | GATATGCCCTACTA | 1 | 0 | 448 | 1061 |
| TS4-ASO | GTATGCCTCCGTTA | 1 | 1 | 2164 | 600 |
| TS5-ASO | GCTATGTTAGTCCG | 0 | 1 | 287 | 291 |
aAll oligonucleotides were fully modified with phosphorothioate linkages. Gap DNA and LNA are indicated in black and green, respectively. C57BL/6J mice (n = 2 animals per group) were intravenously injected with a dose of 20 mg/kg. Ninety-six hours post injection, serum aspartate aminotransferase (AST)/alanine aminotransferase (ALT) levels were determined.