TABLE 2.
Periprosthetic tissue reactions in patients with cup loosening only (n = 10); evaluated with the modified Mirra classification
| Case no. | Neutrophils | Macrophages | Chronic inflammatory cells | Multinucleated giant cells | Metal particles/macrophages | Necrosis |
|---|---|---|---|---|---|---|
| 1‐1 | 0 | 2+ | 1+ | 0 | 2+ | 1+ |
| 1‐2 | 1+ | 3+ | 2+ | 0 | 2+ | 2+ |
| 2‐1 | 1+ | 3+ | 2+ | 0 | 1+ | 1+ |
| 3‐1 | 1+ | 3+ | 3+ | 3+ | 1+ | 1+ |
| 3‐2 | 2+ | 2+ | 2+ | 1+ | 1+ | 1+ |
| 4‐1 | 1+ | 3+ | 2+ | 0 | 1+ | 0 |
| 4‐2 | 1+ | 3+ | 1+ | 0 | 2+ | 0 |
| 5‐1 | 2+ | 3+ | 2+ | 3+ | 0 | 2+ |
| 5‐2 | 0 | 0 | 0 | 0 | 0 | 3+ |
| 6‐1 | NR a | |||||
| 6‐2 | NR a | |||||
| 7‐1 | 0 | 2+ | 2+ | 0 | 1+ | 2+ |
| 7‐2 | 0 | 3+ | 1+ | 1+ | 0 | 0 |
| 8‐1 | 0 | 0 | 0 | 0 | 0 | 3+ |
| 8‐1 | 1+ | 2+ | 1+ | 1+ | 2+ | 1+ |
| 9‐1 | 0 | 3+ | 1+ | 3+ | 1+ | 0 |
| 10‐1 | 0 | 0 | 0 | 0 | 0 | 3+ |
| 10‐2 | 0 | 0 | 0 | 0 | 0 | 3+ |
| Frequency distribution (%) and medians of scores 0 to 3+ | ||||||
|---|---|---|---|---|---|---|
| Neutrophils | Macrophages | Chronic inflammatory cells | Multinucleated giant cells | Metal particles/macrophages | Necrosis | |
| Score | Frequency distribution (%) | |||||
| 0 | 50 | 25 | 25 | 62.5 | 37.5 | 25 |
| 1+ | 37.5 | 0 | 31.25 | 18.5 | 37.5 | 31.25 |
| 2+ | 12.5 | 25 | 37.5 | 0 | 25 | 18.75 |
| 3+ | 0 | 50 | 6.25 | 18.75 | 0 | 25 |
| Median score | 0.5+ | 2.5+ | 1+ | 0 | 1+ | 1+ |
a
NR, not representative. Tissue that is not representative, such as connective tissue or fat tissue. These samples were excluded from the histological examination.