TABLE 3.

Periprosthetic tissue reactions in patients with stem and cup loosening (n = 18); evaluated with the modified Mirra classification

Case no.	Neutrophils	Macrophages	Chronic inflammatory cells	Multinucleated giant cells	Metal particles/macrophages	Necrosis
11‐1	2+	2+	2+	2+	2+	2+
11‐2	1+	3+	2+	1+	2+	1+
12‐1	NR a
12‐2	1+	3+	2+	0	1+	1+
13‐1	1+	3+	1+	0	2+	1+
13‐2	0	0	0	0	0	3+
14‐1	0	2+	1+	0	2+	1+
14‐2	0	3+	2+	0	2+	2+
15‐1	0	3+	2+	2+	2+	0
15‐2	0	3+	2+	2+	2+	0
16‐1	0	2+	1+	0	2+	2+
16‐2	0	3+	2+	0	2+	2+
17‐1	1+	2+	2+	0	2+	0
17‐2	1+	3+	2+	0	2+	0
18‐1	1+	3+	2+	0	1+	1+
18‐2	1+	3+	2+	2+	2+	1+
19‐1	0	3+	1+	2+	2+	0
19‐2	0	2+	2+	2+	2+	0
20‐1	0	3+	2+	1+	1+	1+
20‐2	0	3+	2+	2+	2+	1+
21‐1	1+	3+	1+	3+	2+	1+
22‐1	0	0	0	0	0	3+
23‐1	0	3+	2+	3+	1+	2+
23‐2	1+	3+	2+	2+	1+	2+
24‐1	0	0	0	0	0	3+
24‐2	0	0	0	0	0	3+
25‐1	0	0	0	0	0	3+
25‐2	0	0	0	0	0	3+
26‐1	NR a
26‐2	NR a
27‐1	1+	3+	2+	3+	2+	1+
27‐2	0	3+	2+	0	2+	2+
28‐1	1+	2+	1+	0	1+	2+
28‐2	1+	2+	1+	0	2+	2+

Frequency distribution (%) and medians of scores 0 to 3+
	Neutrophils	Macrophages	Chronic inflammatory cells	Multinucleated giant cells	Metal particles/macrophages	Necrosis
Score	Frequency distribution (%)
0	58.1	19.4	19.4	58.1	19.4	19.4
1+	38.7	0	22.6	6.5	19.4	32.3
2+	3.2	22.6	58.1	25.8	62.3	29.0
3+	0	58.1	0	9.7	0	19.4
Median score	0	3+	2+	0	2+	1+

^a NR, not representative. Tissue that is not representative, such as connective tissue or fat tissue. These samples were excluded from the histological examination.