TABLE 1.
Median willingness to accept risk of death in return for cure of IBS symptoms from a hypothetical medication according to demographics, symptom characteristics and level of psychological comorbidity among 752 individuals with Rome IV IBS
| Median risk of death, % (IQR) | P value* | |
|---|---|---|
| Sex | ||
| Male (n = 97) | 5.00 (1.00‐10.00) | |
| Female (n = 655) | 2.00 (0.00‐8.00) | <0.001 |
| Smoker | ||
| Yes (n = 82) | 3.5 (0.0‐10.0) | |
| No (n = 670) | 2.0 (0.0‐9.0) | 0.15 |
| Alcohol use | ||
| Yes (n = 439) | 2.0 (0.0‐8.0) | |
| No (n = 313) | 2.0 (0.0‐10.0) | 0.48 |
| Married | ||
| Yes (n = 487) | 2.0 (0.0‐7.0) | |
| No (n = 265) | 3.0 (0.0‐10.0) | 0.02 |
| University or postgraduate level of education | ||
| Yes (n = 314) | 2.0 (0.0‐6.0) | |
| No (n = 438) | 2.0 (0.0‐10.0) | 0.15 |
| Annual income of £30,000 or more | ||
| Yes (n = 197) | 3.0 (0.0‐9.0) | |
| No (n = 483) | 2.0 (0.0‐9.0) | 0.34 |
| IBS subtype | ||
| IBS‐C (n = 136) | 1.0 (0.0‐5.0) | |
| IBS‐D (n = 306) | 2.0 (0.0‐8.25) | |
| IBS‐M (n = 301) | 3.0 (0.0‐10.0) | 0.14 |
| Most troublesome symptom | ||
| Abdominal pain (n = 169) | 3.0 (0.0‐10.0) | |
| Constipation (n = 53) | 2.0 (0.0‐9.0) | |
| Diarrhoea (n = 117) | 4.0 (0.0‐10.0) | |
| Bloating/distension (n = 218) | 2.0 (0.0‐5.0) | |
| Urgency (n = 195) | 2.0 (0.0‐9.0) | 0.11 |
| Continuous abdominal pain | ||
| Yes (n = 345) | 4.0 (0.0‐10.0) | |
| No (n = 407) | 1.0 (0.0‐5.0) | <0.001 |
| Self‐rated risk‐taking behaviour | ||
| Never (n = 66) | 0.0 (0.0‐4.0) | |
| Rarely (n = 343) | 2.0 (0.0‐6.0) | |
| Occasionally (n = 323) | 3.0 (0.0‐10.0) | |
| Routinely (n = 20) | 3.5 (0.0‐31.25) | <0.001 |
| Duration of IBS diagnosis, year(s) | ||
| 1 (n = 25) | 2.0 (0.0‐5.0) | |
| 2 (n = 41) | 2.0 (0.0‐6.5) | |
| 3 (n = 54) | 3.0 (0.0‐11.25) | |
| 4 (n = 33) | 1.0 (0.0‐9.0) | |
| 5 (n = 38) | 3.0 (0.0‐9.25) | |
| >5 (n = 561) | 2.0 (0.0‐9.0) | 0.56 |
| Number of IBS drugs in the last 12 months | ||
| 0 (n = 96) | 1.0 (0.0‐5.0) | |
| 1 (n = 189) | 1.0 (0.0‐7.0) | |
| 2 (n = 196) | 2.0 (0.0‐9.0) | |
| 3 (n = 129) | 4.0 (0.0‐10.0) | |
| 4 (n = 76) | 3.0 (0.0‐10.0) | |
| ≥5 (n = 66) | 4.0 (0.0‐10.0) | 0.005 |
| Severity on IBS‐SSS | ||
| Mild (n = 86) | 2.0 (0.0‐5.0) | |
| Moderate (n = 300) | 1.0 (0.0‐7.0) | |
| Severe (n = 359) | 3.0 (0.0‐10.0) | 0.005 |
| HADS anxiety categories | ||
| Normal (n = 200) | 2.0 (0.0‐5.0) | |
| Borderline abnormal (n = 174) | 2.0 (0.0‐8.25) | |
| Abnormal (n = 378) | 2.5 (0.0‐10.0) | 0.20 |
| HADS depression categories | ||
| Normal (n = 404) | 2.0 (0.0‐5.0) | |
| Borderline abnormal (n = 165) | 2.0 (0.0‐8.5) | |
| Abnormal (n = 183) | 5.0 (0.0‐15.0) | <0.001 |
| PHQ‐12 severity | ||
| Low (n = 36) | 2.0 (0.0‐5.0) | |
| Mild (n = 176) | 2.0 (0.0‐9.0) | |
| Moderate (n = 307) | 2.0 (0.0‐6.0) | |
| Severe (n = 233) | 4.0 (0.0‐10.0) | 0.14 |
| VSI scores | ||
| Low (n = 247) | 1.0 (0.0‐5.0) | |
| Medium (n = 247) | 2.0 (0.0‐9.0) | |
| High (n = 258) | 3.0 (0.0‐10.0) | <0.001 |
| IBS‐QOL scores | ||
| Low (n = 239) | 4.0 (0.0‐10.0) | |
| Medium (n = 252) | 2.0 (0.0‐9.0) | |
| High (n = 261) | 1.0 (1.0‐5.0) | <0.001 |
*
P value for Mann‐Whitney U test for 2 groups and for Kruskal‐Wallis test for 3 groups or more.