TABLE 2.
Characteristics of individuals with Rome IV IBS willing to accept above median risk of death in return for cure of IBS symptoms from a hypothetical medication compared with median or below median risk of death
|
Above median risk of death (n = 356) |
Median or below median risk of death (n = 396) |
P value* | |
|---|---|---|---|
| Female (%) | 295 (82.9) | 360 (90.9) | 0.001 |
| Mean age (SD) | 45.7 (14.7) | 45.0 (14.9) | 0.54 |
| White ethnicity (%) | 346 (97.2) | 383 (96.7) | 0.71 |
| Married (%) | 216 (60.7) | 270 (68.4) | 0.03 |
| Smoker (%) | 45 (12.6) | 37 (9.3) | 0.15 |
| Alcohol user (%) | 200 (56.2) | 239 (60.4) | 0.25 |
| University or postgraduate level of education (%) | 140 (39.3) | 174 (43.9) | 0.20 |
| Annual income of £30,000 or more (%) | 102 (31.1) | 95 (27.0) | 0.24 |
| IBS subtype (%) | |||
| IBS‐C | 55 (15.5) | 81 (20.8) | |
| IBS‐D | 146 (41.2) | 160 (41.1) | |
| IBS‐M | 153(43.2) | 148 (38.0) | 0.13 |
| Most troublesome symptom (%) | |||
| Abdominal pain | 87 (24.4) | 82 (20.7) | |
| Constipation | 26 (7.3) | 27 (6.8) | |
| Diarrhoea | 62 (17.4) | 55 (13.9) | |
| Bloating/distension | 92 (25.8) | 126 (31.8) | |
| Urgency | 89 (25.0) | 106 (26.8) | 0.26 |
| Continuous abdominal pain (%) | 189 (53.1) | 156 (39.4) | <0.001 |
| Self‐rated risk‐taking behaviour (%) | |||
| Never | 21 (5.9) | 45 (11.4) | |
| Rarely | 153 (43.0) | 190 (48.0) | |
| Occasionally | 171 (48.0) | 152 (38.4) | |
| Routinely | 11 (3.1) | 9 (2.3) | 0.008 |
| Duration of IBS diagnosis, year(s) (%) | |||
| 1 | 9 (2.5) | 16 (4.0) | |
| 2 | 16 (4.5) | 25 (6.3) | |
| 3 | 28 (7.9) | 26 (6.6) | |
| 4 | 13 (3.7) | 20 (5.1) | |
| 5 | 20 (5.6) | 18 (4.5) | |
| >5 | 270 (75.8) | 291 (73.5) | 0.51 |
| Number of IBS drugs in the last 12 months (%) | |||
| 0 | 40 (11.2) | 56 (14.1) | |
| 1 | 80 (22.5) | 109 (27.5) | |
| 2 | 90 (25.3) | 106 (26.8) | |
| 3 | 69 (19.4) | 60 (15.2) | |
| 4 | 41 (11.5) | 35 (8.8) | |
| ≥5 | 36 (10.1) | 30 (7.6) | 0.16 |
| IBS‐SSS severity (%) | |||
| Mild | 33 (9.3) | 53 (13.4) | |
| Moderate | 132 (37.1) | 168 (42.4) | |
| Severe | 189 (53.1) | 170 (42.9) | 0.02 |
| HADS anxiety categories (%) | |||
| Normal | 84 (23.6) | 116 (29.3) | |
| Borderline abnormal | 83 (23.3) | 91 (23.0) | |
| Abnormal | 189 (53.1) | 189 (47.7) | 0.19 |
| HADS depression categories (%) | |||
| Normal | 171 (48.0) | 233 (58.8) | |
| Borderline abnormal | 81 (22.8) | 84 (21.2) | |
| Abnormal | 104 (29.2) | 79 (19.9) | 0.004 |
| PHQ‐12 severity (%) | |||
| Low | 16 (4.5) | 20 (5.1) | |
| Mild | 81 (22.8) | 95 (24.0) | |
| Moderate | 132 (37.1) | 175 (44.2) | |
| Severe | 127 (35.7) | 106 (26.8) | 0.06 |
| VSI scores (%) | |||
| Low | 101 (28.4) | 146 (36.9) | |
| Medium | 118 (33.1) | 129 (32.6) | |
| High | 137 (38.5) | 121 (30.6) | 0.02 |
| IBS‐QOL score (%) | |||
| Low | 133 (37.4) | 106 (26.8) | |
| Medium | 124 (34.8) | 128 (32.3) | |
| High | 99 (27.8) | 162 (40.9) | <0.001 |
| WPAI: IBS, median % (IQR) | |||
| Absenteeism | 0.0 (0.0‐5.1) | 0.0 (0.0‐1.3) | 0.10 |
| Presenteeism | 40.0 (20.0‐60.0) | 30.0 (10.0‐60.0) | 0.002 |
| Overall work impairment | 40.0 (15.9‐65.3) | 30.0 (10.0‐57.1) | 0.004 |
| Activity impairment | 50.0 (30.0‐70.0) | 40.0 (20.0‐60.0) | <0.001 |
*
P value for Pearson χ2 for comparison of categorical data, independent samples t‐test for age, and Mann‐Whitney U test for all four dimensions of Work Productivity and Activity Impairment: Irritable Bowel Syndrome.