Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Growth inhibition of androgen negative human prostate cancer cells DU145 by potent σ1 ligands.
|
| |||
|---|---|---|---|
|
Compd |
NR2 |
σ1 affinity K i±SEM [nM] |
cytotoxicity (DU145) IC 50 [μM] |
|
20a |
NHCH2C6H11 |
16±5 |
4.9 |
|
21a |
N(CH3)CH2Ph |
19±9 |
5.5 |
|
22a |
|
27±11 |
4.0 |
|
NE‐100 |
|
1.3 [63] |
>10 |
|
S1RA |
|
17±7.0 [64] |
>10 |
σ1 affinity and cytotoxicity represent the data of three experiments (n=3).
