TABLE 6.

Univariate and multivariate analysis of factors defining the risk of death at 28 days

	OR (95% CI)	P	Multivariate model 1 (OR)	Multivariate model 1 (P)	Multivariate model 2 (OFs) (OR)	Multivariate model 2 (P)
Age (years)	1.013 (1.002–1.025)	0.019	1.022 (1.008–1.036)	0.003	1.014 (1.000–1.029)	0.052
Sex (Female)	0.727 (0.521–1.015)	0.061	0.850 (0.575–1.256)	0.414	0.799 (0.539–1.185)	0.265
TLC (×109)	1.043 (1.022–1.064)	<0.001	1.012 (0.989–1.037)	0.307	1.006 (0.983–1.030)	0.623
INR	1.742 (1.493–2.033	<0.001	1.579 (1.320–1.889)	<0.001
Creatinine (mg/dl)	1.391 (1.241–1.559)	<0.001	1.160 (1.032–1.304)	0.013
Total bilirubin (mg/dl)	1.013 (1.000–1.027)	0.058	1.013 (0.995–1.031)	0.151
Albumin (g/dl)	0.745 (0.600–0.926)	0.008	0.862 (0.667–1.114)	0.257	0.878 (0.679–1.135)	0.320
Mean arterial pressure (mm Hg)	0.988 (0.978–0.998)	0.022	0.995 (0.986–1.003)	0.240
Overt‐HE	3.724 (2.744–5.053)	<0.001
Organ failures
HE	4.462 (3.064–6.497)	<0.001
Liver	1.378 (1.021–1.859)	0.036			1.814 (1.215–2.708)	0.004
Kidney	3.982 (2.873–5.519)	<0.001			2.442 (1.669–3.572)	<0.001
Coagulation	3.355 (2.456–4.583)	<0.001			2.781 (1.930–4.007)	<0.001
Circulatory	2.213 (1.567–3.125)	<0.001			1.534 (1.007–2.337)	0.046
Respiratory	2.605 (1.930–3.518)	<0.001			2.057 (1.403–3.017)	<0.001
Baseline HE and infection groups
No baseline HE no infection	1		1		1
Overt HE no baseline infection	4.466 (3.113–6.408)	<0.001	3.711 (2.488–5.536)	<0.001	3.312 (2.193–5.002)	<0.001
No baseline HE baseline infection	3.612 (2.277–5.730)	<0.001	3.181 (1.918–5.275)	<0.001	3.018 (1.802–5.053)	<0.001
Overt HE baseline infection	7.634 (4.498–12.956)	<0.001	5.388 (3.021–9.611)	<0.001	4.586 (2.540–8.277)	<0.001

Abbreviations: HE, hepatic encephalopathy; INR, international normalised ratio; TLC, total leucocyte count.