Table 3.
Predictive values for serum levels of HBsAg, AST, and age for identifying significant histological changes in HBeAg-negative patients (n = 392).
| G2 or S2 (ALT ≤80 IU/L) | |||||||
|---|---|---|---|---|---|---|---|
| Yes | NO | PPV (%) | Sensitivity (%) | NPV (%) | Specificity (%) | ||
| HBsAg ≥1000 IU/ml | YES | 199 | 37 | 84.3 | 65.3 | 32.1 | 57.5 |
| NO | 106 | 50 | |||||
| Age >40 years | YES | 174 | 42 | 80.6 | 57.1 | 25.6 | 51.7 |
| NO | 131 | 45 | |||||
| AST >25 IU/L | YES | 195 | 36 | 84.4 | 63.9 | 31.7 | 58.6 |
| NO | 110 | 51 | |||||
| HBsAg ≥1000 IU/ml and age >40 years and ALT >25 IU/L | YES | 70 | 6 | 92.1 | 23.0 | 25.6 | 93.1 |
| NO | 235 | 81 | |||||
PPV, positive predictive value; NPV, negative predictive value.