Figure 6.

miR-21 regulates HCECs' proliferation and migration by activating PI3K/Akt pathway through targeting PTEN. (a, d) HUMSC-sEV treatment decreased the RNA and protein levels of PTEN in HCECs. (b) The expression level of miR-21 in HCECs. (c, f) The PTEN changed with miR-21 variation. (e) The expression of phospho-Akt after overexpression of PTEN. (g) The expression level of phospho-Akt after transfected with miR-21 mimics was detected by Western blot. Data are expressed as the means ± SD. ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001.