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Drivers of plaque formation in psoriasis. Proinflammatory chemotactic factors: CXCL1 (C‐X‐C motif chemokine ligand 1), interleukin (IL)‐8 (encoded by CXCL8) and CCL20 (C‐C motif chemokine 20); upstream cytokines: IL‐17A, IL‐17F, IL‐23A and IL‐12B; markers of epithelial stress: IL‐19, IL‐36γ and IL‐36α; proliferation: KRT16; antimicrobial peptide: S100A7. TNF, tumour necrosis factor. The T17 cell represents IL‐17‐producing T cells (including cytotoxic T cells and T helper cells).
