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. 2022 Feb 15;62(4):505–519. doi: 10.1002/jcph.1980

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© 2021 Pfizer Inc. The Journal of Clinical Pharmacology published by Wiley Periodicals LLC on behalf of American College of Clinical Pharmacology

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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graphic file with name JCPH-62-505-g008.jpg — Linear regression plots of ln AUC_inf vs eGFR for abrocitinib (A), M1 (B), M2 (C), M4 (D), and abrocitinib active moiety (E). AUC_inf, area under the concentration‐time curve from time 0 extrapolated to infinite time; eGFR, estimated glomerular filtration rate; ln, natural log.

graphic file with name JCPH-62-505-g001.jpg — Linear regression plots of ln AUC_inf vs eGFR for abrocitinib (A), M1 (B), M2 (C), M4 (D), and abrocitinib active moiety (E). AUC_inf, area under the concentration‐time curve from time 0 extrapolated to infinite time; eGFR, estimated glomerular filtration rate; ln, natural log.