Table 1.
Demographics and Baseline Characteristics of Study Subjects
| Normal Renal Function, N = 8 | Moderate Renal Impairment, N = 7 | Severe Renal Impairment, N = 8 | |
|---|---|---|---|
| Age, y, mean (SD) | 59.8 (4.7) | 65.7 (8.3) | 61.0 (14.5) |
| Sex, n (%) | |||
| Male | 6 (75.0) | 3 (42.9) | 7 (87.5) |
| Female | 2 (25.0) | 4 (57.1) | 1 (12.5) |
| Race, n (%) | |||
| White | 6 (75.0) | 6 (85.7) | 7 (87.5) |
| Black or African American | 1 (12.5) | 1 (14.3) | 1 (12.5) |
| Multiracial | 1 (12.5) | 0 | 0 |
| Weight (kg) | |||
| Mean (SD) | 86.1 (6.6) | 82.2 (11.6) | 79.4 (16.5) |
| Range (minimum, maximum) | (77.9, 93.7) | (66.8, 97.0) | (54.4, 100.4) |
| Body mass index (kg/m2) | |||
| Mean (SD) | 28.4 (2.1) | 30.3 (5.7) | 27.7 (5.3) |
| Range (minimum, maximum) | (25.1, 32.2) | (24.4, 39.6) | (20.3, 36.7) |
| eGFR (mL/min), mean (SD) | 112. 4 (21.3) | 43.4 (9.4) | 15.6 (8.4) |
eGFR, estimated glomerular filtration rate, calculated using the Modification of Diet in Renal Disease equation; SD, standard deviation.