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The time course of the biomarkers presented as observed mean absolute change from baseline since first dose, grouped by placebo and tertile of Css,av. Measurements from unscheduled visits are not included in the plot. Css,av, average concentration at steady state; FeNO, fraction exhaled nitric oxide; FEV1, forced expiratory volume in 1 second; sST2, soluble ST2.
