TABLE 1.

Receptor binding profile of chlorprothixene with receptors involved in metabolic dysregulation in comparison with other antipsychotics associated with metabolic adverse events

	Antipsychotic
Receptor	Chlorprothixene	Quetiapine	Olanzapine	Clozapine
D2	5.6	770	20	210
5‐HT1A	138	300	610	160
5‐HT2C	4.5	3500	4.1	4.8
α2	186	80	280	158
H1	3.8	19	0.1	3.1
M3	22	1320	126	109

Note: All numbers represent Ki in nM. Based on Correll ¹⁰ and Besnard et al. ⁹