TABLE 5.
Meta‐regression analysis of the effect of type 1 diabetes on aortic intima media thickness
| Variable, Unit | Number of studies | Change in aIMT (95% CI) | p value |
|---|---|---|---|
| Age, years | 9 | 0.014 (−0.016, 0.044) | 0.358 |
| Diabetes duration, years | 8 | 0.039 (0.020, 0.058) | <0.001 |
| Insulin dose, IU/kg/day | 5 | 0.335 (0.171, 0.499) | <0.001 |
| BMI, kg/m2 | 5 | 0.039 (0.011, 0.067) | 0.006 |
| BMI, z score | 4 | 0.789 (0.432, 1.147) | <0.001 |
| Waist circumference, cm | 4 | 0.018 (0.009, 0.027) | <0.001 |
| HbA1c, % | 7 | −0.005 (−0.131, 0.122) | 0.942 |
| Fasting glucose, mg/dl | 5 | 0.001 (−0.043, 0.045) | 0.967 |
| Systolic BP, mmHg | 7 | 0.016 (−0.001, 0.032) | 0.063 |
| Diastolic BP, mmHg | 7 | 0.010 (0.000, 0.019) | 0.049 |
| Total cholesterol, mg/dl | 8 | 0.004 (−0.001, 0.010) | 0.129 |
| LDL cholesterol, mg/dl | 7 | 0.006 (0.003, 0.009) | <0.001 |
| HDL cholesterol, mg/dl | 8 | −0.007 (−0.018, 0.004) | 0.226 |
| Triglycerides, mg/dl | 7 | 0.004 (0.001, 0.008) | 0.018 |
Abbreviations: aIMT, aortic intima media thickness; NR, not reported.