TABLE 2.

Treatments and outcomes of patients with HLH during pregnancy

Case	Timing of diagnosis and treatment	Treatment and outcome	Complications	Gestation (weeks), delivery method	Maternal/fetal survival
1	Prepartum	Corticosteroids	Stillbirth	20, CS	Yes/no
2	Prepartum	Corticosteroids, IVIG	Miscarriage	19, CS	Yes/no
3	Prepartum	Corticosteroids, IVIG	Miscarriage	19, medical abortion	Yes/no
4	Prepartum	Methylprednisolone and IVIG treatment failed, remission with methylprednisolone and IVIG after delivery	PROM, preterm labor	29, VD	Yes/no
5	Prepartum	Dexamethasone and IVIG treatment failed	Stillbirth	23 + 5, VD	No/no
6	Prepartum	Corticosteroids and etoposide treatment failed, remission with dexamethasone, IVIG, etoposide, and cyclosporine after cesarean section	SGA	31, CS	Yes/yes
7	Postpartum	Remission with corticosteroids		37, CS	Yes/yes
8	Postpartum	Corticosteroid treatment failed	Preterm labor	36, CS	No/yes
9	Postpartum	Remission with corticosteroids, IVIG, cyclosporine	Miscarriage	18, medical abortion	Yes/no
10	Postpartum	Remission with dexamethasone, IVIG, etoposide		38, CS	Yes/yes
11	Postpartum	Methylprednisolone, IVIG, and etoposide treatment failed		37, CS	No/yes
12	Postpartum	Dexamethasone treatment failed, remission with dexamethasone and etoposide	PROM	26, VD	Yes/no
13	Postpartum	Failed with IVIG	Miscarriage	8, curettage	No/no

Abbreviations: CS, cesarean section; HLH, hemophagocytic lymphohistiocytosis; IVIG, intravenous immunoglobulin; PROM, premature rupture of the membranes; SGA, small for gestational age; VD, vaginal delivery.