TABLE 1.
Histology‐ and stage‐specific cancer cases in three cancer registries a in Japan, 1993 to 2015, by period of diagnosis
| Characteristic | Male | Female | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall, N = 44 113 b | 1993‐1999, N = 10 807 b | 2000‐2004, N = 9215 b | 2005‐2009, N = 10 559 b | 2010‐2015, N = 13 532 b | P‐value c | Overall, N = 18 757 b | 1993‐1999, N = 4141 b | 2000‐2004, N = 3834 b | 2005‐2009, N = 4498 b | 2010‐2015, N = 6284 b | P‐value c | |
| Histological type | <.001 | <.001 | ||||||||||
| Small cell carcinoma | 4593 (10.4%) | 1206 (11.2%) | 988 (10.7%) | 1060 (10.0%) | 1339 (9.9%) | 822 (4.4%) | 214 (5.2%) | 165 (4.3%) | 201 (4.5%) | 242 (3.9%) | ||
| Squamous cell carcinoma | 10 950 (24.8%) | 3001 (27.8%) | 2273 (24.7%) | 2536 (24.0%) | 3140 (23.2%) | 1223 (6.5%) | 318 (7.7%) | 250 (6.5%) | 271 (6.0%) | 384 (6.1%) | ||
| Adenocarcinoma | 15 344 (34.8%) | 3403 (31.5%) | 3103 (33.7%) | 3732 (35.3%) | 5106 (37.7%) | 10 963 (58.4%) | 2243 (54.2%) | 2161 (56.4%) | 2645 (58.8%) | 3914 (62.3%) | ||
| Large cell carcinoma | 914 (2.1%) | 304 (2.8%) | 203 (2.2%) | 194 (1.8%) | 213 (1.6%) | 182 (1.0%) | 72 (1.7%) | 51 (1.3%) | 30 (0.7%) | 29 (0.5%) | ||
| Other nonsmall cell carcinoma | 603 (1.4%) | 107 (1.0%) | 71 (0.8%) | 156 (1.5%) | 269 (2.0%) | 188 (1.0%) | 35 (0.8%) | 32 (0.8%) | 38 (0.8%) | 83 (1.3%) | ||
| Other specified and unspecified types | 7071 (16.0%) | 1753 (16.2%) | 1551 (16.8%) | 1737 (16.5%) | 2030 (15.0%) | 3095 (16.5%) | 735 (17.7%) | 658 (17.2%) | 735 (16.3%) | 967 (15.4%) | ||
| 8010 | 4093 (9.3%) | 1006 (9.3%) | 883 (9.6%) | 949 (9.0%) | 1255 (9.3%) | 2125 (11.3%) | 514 (12.4%) | 466 (12.2%) | 519 (11.5%) | 626 (10.0%) | ||
| 8046 | 545 (1.2%) | 27 (0.2%) | 143 (1.6%) | 195 (1.8%) | 180 (1.3%) | 159 (0.8%) | 10 (0.2%) | 51 (1.3%) | 59 (1.3%) | 39 (0.6%) | ||
| Stage at diagnosis | <.001 | <.001 | ||||||||||
| Localized | 9267 (21.0%) | 1766 (16.3%) | 1596 (17.3%) | 2227 (21.1%) | 3678 (27.2%) | 5763 (30.7%) | 929 (22.4%) | 979 (25.5%) | 1413 (31.4%) | 2442 (38.9%) | ||
| Regional | 11 243 (25.5%) | 2904 (26.9%) | 2290 (24.9%) | 2840 (26.9%) | 3209 (23.7%) | 3367 (18.0%) | 852 (20.6%) | 730 (19.0%) | 853 (19.0%) | 932 (14.8%) | ||
| Distant | 13 314 (30.2%) | 2864 (26.5%) | 2359 (25.6%) | 3251 (30.8%) | 4840 (35.8%) | 5066 (27.0%) | 1017 (24.6%) | 945 (24.6%) | 1149 (25.5%) | 1955 (31.1%) | ||
| Unknown | 5895 (13.4%) | 1773 (16.4%) | 1642 (17.8%) | 1330 (12.6%) | 1150 (8.5%) | 2434 (13.0%) | 707 (17.1%) | 613 (16.0%) | 568 (12.6%) | 546 (8.7%) | ||
| Missing | 4394 (10.0%) | 1500 (13.9%) | 1328 (14.4%) | 911 (8.6%) | 655 (4.8%) | 2127 (11.3%) | 636 (15.4%) | 567 (14.8%) | 515 (11.4%) | 409 (6.5%) | ||
| Death certificate notification | 8433 (19.1%) | 2564 (23.7%) | 2356 (25.6%) | 2107 (20.0%) | 1406 (10.4%) | <.001 | 3652 (19.5%) | 1033 (24.9%) | 945 (24.6%) | 961 (21.4%) | 713 (11.3%) | <.001 |
| Death certificate only | 4373 (9.9%) | 1498 (13.9%) | 1323 (14.4%) | 899 (8.5%) | 653 (4.8%) | <.001 | 2111 (11.3%) | 636 (15.4%) | 561 (14.6%) | 507 (11.3%) | 407 (6.5%) | <.001 |
| MV% | 33 341 (75.6%) | 8149 (75.4%) | 6784 (73.6%) | 7940 (75.2%) | 10 468 (77.4%) | <.001 | 13 630 (72.7%) | 2937 (70.9%) | 2702 (70.5%) | 3268 (72.7%) | 4723 (75.2%) | <.001 |
| Proportion of autopsy | 9 (0.0%) | 0 (0.0%) | 2 (0.0%) | 3 (0.0%) | 4 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | ||
Abbreviation: MV, morphological verification.
a
The three Japanese cancer registries are in Yamagata, Fukui and Nagasaki prefectures.
b
Frequency (%).
c
Pearson's chi‐squared test.