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Gs bias for INT-777 and β-arrestin bias for R399 contributed to the distinct biological consequences elicited in NSCLC. (A–C) Comparison of the biased properties of INT-777 and R399. Both INT-777 and R399 were assessed for cAMP signaling (A) and β-arrestin 1/2 recruitment (B and C). BRET, bioluminescence resonance energy transfer; CTRL, control; ns, not significant; RLU, Renilla Luciferase.
