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The proposed role of the Hippo pathway in axis formation in Hydra. (A) Schematic drawings of the axial distributions of epithelial cell density (adapted from ref. 10) and nuclear HyYap superimposed over Hyβ-catenin in situ (adapted from ref. 12). (B) Hypothetical model identifying HyYap as a molecular link between cell division and axis formation in Hydra. Dotted arrow indicates causal connection based on analogy with Drosophila and mammals that yet has to be demonstrated in Hydra.
