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. 2022 Jul 14;119(29):e2204527119. doi: 10.1073/pnas.2204527119

Fig. 5.

Fig. 5.

Astrocytic IRs modulate brain angiogenesis. (A) Brain levels of vWF in young (Left histograms) and aged (Right histograms) GFAP-IR KO and littermate mice (n = 10; t test, t = 3.56, *P < 0.05). (B) Vessel volume in the somatosensorial cortex of young (Upper) and aged (Lower) GFAP-IR KO mice and controls (n = 9; t test, t = 3.28, **P < 0.01). Vessels were identified with Fluorescein isothiocyanate (FITC)-labeled tomato lectin and quantified (Lower histograms: Left, young mice and Right, older mice). (C and D) Protein levels of VEGFa and HIF-1α in young (C) and aged GFAP-IR KO mice and littermates (D) (n = 9; t test, t = 3.12, *P < 0.05 and ***P < 0.001).