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. 2022 Jul 12;119(29):e2113545119. doi: 10.1073/pnas.2113545119

Fig. 2.

Fig. 2.

L-AChR are still activated in wild type and lev-10 after 1 h of 1 mM levamisole exposure. (A) Membrane resting potentials of muscle cells in wild type (n = 14), lev-10 (n = 14), wild type exposed to 1 mM levamisole during 1 h (n = 12), and lev-10 exposed to 1 mM levamisole during 1 h (n = 14). For animals placed on levamisole plates, levamisole was also added in the external solution at the concentration of 0.01 mM; ANOVA, P < 0.0001; Holm-Sidak posttests, P < 0.001 for all except for wild type/lev-10 without levamisole. (B) Effect of dTBC on membrane resting potentials of muscle cells in wild type (n = 9) and lev-10 (n = 9) exposed to 1 mM levamisole. Animals were placed on 1 mM levamisole plates for 1 h; levamisole was also added in the external medium at the concentration of 0.01 mM. dTBC at 0.1 mM was perfused while membrane potential was recorded. dTBC induced a significant repolarization of muscle cells in wild type and lev-10 (paired sample test, P = 0.0001 and P = 0.0004, respectively).