Fig. 6.

SIK3-cKO alleviated long-term demyelination and bundle atrophy after tFCI. a Representative images of NeuN immunostaining 35d after tFCI. b Quantification of infarct volume/area 35d after tFCI. n = 5/group. c Representative images of MBP immunostaining in STR 35d after tFCI (scale bar = 100 µm). d Quantification of the MBP density in the penumbra of STR 35d after tFCI. e Quantification of the number of fiber bundles in the whole STR 35d after tFCI. f Quantification of the average area of each bundle, and the percentage of fiber bundle area in the whole STR 35d after tFCI. n = 4–5/group. *p < 0.05, **p < 0.01, ****p < 0.0001. ns: no significant, as indicated. One-way ANOVA or two-way ANOVA or Mutiple t tests were used to assess statistical analysis